Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus. Issue 11 (17th November 2016)

• Record Type: Journal Article
• Authors: Weiss, Andy; Fleeman, Renee M.; Shaw, Lindsey N.
• Is Part Of: Cell chemical biology. Volume 23:Issue 11(2016)
• Page Start: 1317
• Page End: 1319
• Publication Date: 2016-11-17
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2016.11.003
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : In this issue of Cell Chemical Biology, Choby et al. (2016) use a small molecule inhibitor active against fermenting S. aureus to unravel a unique connection between virulence factor production and central metabolism. In so doing, the authors uncover Fe-S cluster assembly proteins as a novel antibacterial target, and deliver a first-in-class scaffold for optimization against anaerobically growing cells. Abstract : In this issue of Cell Chemical Biology, Choby et al. (2016) use a small molecule inhibitor active against fermenting S. aureus to unravel a unique connection between virulence factor production and central metabolism. In so doing, the authors uncover Fe-S cluster assembly proteins as a novel antibacterial target, and deliver a first-in-class scaffold for optimization against anaerobically growing cells.