A new drug design strategy: Killing drug resistant bacteria by deactivating their hypothetical genes. (1st October 2016)

• Record Type: Journal Article
• Authors: Wong, Tit-Yee; Kuo, Jimmy
• Is Part Of: Journal of environmental science and health. Volume 34:Number 4(2016)
• Page Start: 276
• Page End: 292
• Publication Date: 2016-10-01
• Subjects: Antibiotic resistance -- drug targets -- genome organization -- hypothetical genes -- stop codon signals; Carcinogenesis -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmentally induced diseases -- Periodicals; Environmental Health -- periodicals; Carcinogens, Environmental -- periodicals; Hazardous Substances -- periodicals; 616.994071
• DOI: 10.1080/10590501.2016.1236605
• Languages: English
• ISSNs: 1059-0501

Abstract

ABSTRACT: Despite that a bacterial genome is complicated by large numbers of horizontally transferred (HT) genes and function unknown hypothetical (FUN) genes, the Genic-Transcriptional-Stop-Signals-Ratio (TSSR) of a genome shows that HT and FUN genes are complementary to all other genes in the genome. When HT or certain FUN genes are omitted from the Escherichia coli K-12 genome, its Genomic-TSSR value becomes totally incomparable to other E. coli strains. The Genic-TSSR correlation tree of a pathogen shows that some FUN genes would form a unique cluster. Removing these genes by site-specific mutation or gene-knockout should lead to the demise of this pathogen.