Deferiprone Enhances Temozolomide Cytotoxicity in Glioma Cells. (25th November 2016)

• Record Type: Journal Article
• Authors: Alexiou, George A.; Gerogianni, Paraskevi; Vartholomatos, Evrysthenis; Kyritsis, Athanasios P.
• Is Part Of: Cancer investigation. Volume 34:Number 10(2016)
• Page Start: 489
• Page End: 495
• Publication Date: 2016-11-25
• Subjects: Glioma -- temozolomide -- deferiprone; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2016.1233424
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: Glioblastoma is the most malignant primary brain tumor with a median survival of 15 months. Temozolomide (TMZ) is the standard of care for these patients. Iron chelators have been shown to have anti-tumor activity; however, deferiprone (DFP), an orally administered iron chelator, has not been previously evaluated in gliomas. In the present study, we found that combination treatment in glioma cells with TMZ and DFP significantly reduced cell viability, produced cell cycle arrest at G2/M phase, and enhanced apoptosis. TMZ and DFP might be a potent new combination treatment for glioblastoma.