Immune activation, smoking, and vaccine response. (2nd January 2017)

• Record Type: Journal Article
• Authors: Younas, Mehwish; Carrat, Fabrice; Desaint, Corinne; Launay, Odile; Corbeau, Pierre
• Other Names: collaborator.
• Is Part Of: AIDS. Volume 31:Number 1(2017)
• Page Start: 171
• Page End: 173
• Publication Date: 2017-01-02
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000001311
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : Here, we tested the hypothesis that chronic immune activation might fuel interindividual variability in vaccine response in the model of hepatitis B virus vaccine in HIV-1-infected adults. We observed that the marker of inflammation soluble tumour necrosis factor receptor I (sTNFRI) is predictive for vaccine efficiency. We also established that the link between tobacco smoking and impaired vaccine response might be mediated by inflammation. These data are a step forward in personalized vaccination.