Rapid quantitative T2 mapping of the prostate using three‐dimensional dual echo steady state MRI at 3T. Issue 6 (13th January 2016)

• Record Type: Journal Article
• Authors: Dregely, Isabel; Margolis, Daniel A. J.; Sung, Kyunghyun; Zhou, Ziwu; Rangwala, Novena; Raman, Steven S.; Wu, Holden H.
• Is Part Of: Magnetic resonance in medicine. Volume 76:Issue 6(2016)
• Page Start: 1720
• Page End: 1729
• Publication Date: 2016-01-13
• Subjects: prostate cancer imaging -- T2 mapping -- dual echo steady state (DESS) MRI -- 3T MRI; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.26053
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To develop and evaluate a rapid three‐dimensional (3D) quantitative T2 mapping method for prostate cancer imaging using dual echo steady state (DESS) MRI at 3T. Methods: In simulations, DESS‐T2 mapping in the presence of T1 and B 1 + variations was evaluated. In a phantom and in healthy volunteers (n = 4), 3D DESS‐T2 mapping was compared with a two‐dimensional turbo spin echo (TSE) approach. In volunteers and a pilot patient study (n = 29), quantitative T2 in normal prostate anatomical zones and in suspected cancerous lesions was evaluated. Results: The simulated bias for DESS‐T2 was < 2% (5%) for typically observed T1 ( B 1 + ) variations. In phantoms and in vivo, high correlation of DESS‐T2 and TSE‐T2 (r 2 = 0.98 and 0.88, P < 0.001) was found. DESS‐T2 in the normal peripheral zone and transition zone was 115 ± 26 ms and 64 ± 7 ms, respectively, in healthy volunteers and 129 ± 39 ms and 83 ± 12 ms, respectively, in patients. In suspected cancerous lesions, DESS‐T2 was 72 ± 14 ms, which was significantly decreased from the normal peripheral zone ( P < 0.001) but not from the transition zone. Conclusion: Rapid 3D T2 mapping in the entire prostate can be performed in 1 min using DESS MRI. Magn Reson Med 76:1720–1729, 2016. © 2016 International Society for Magnetic Resonance in Medicine