Isolation and identification of a new saponin from Cephalaria aytachii. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Kayce, Peyker; Kirmizigul, Suheyla
• Is Part Of: Natural product research. Volume 31:Issue 1(2017)
• Page Start: 50
• Page End: 57
• Publication Date: 2017-01-02
• Subjects: Aytachoside A -- Dipsacaceae -- Cephalaria aytachii -- triterpene saponin -- antimicrobial activity -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1212029
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new hederagenin-type triterpenoid glycoside (1 ) named Aytachoside A, along with eight known triterpene glycosides, were isolated from the aerial parts of Cephalaria aytachii Gokturk and Sumbul (Dipsacaceae) . The structures of compounds1 –9 were determined by spectroscopic (1D and 2D NMR, HRESIMS) and chemical examinations. The antimicrobial effect of compound1 was found considerably active against Escherichia coli, Pseudomonas aeruginosa and especially Salmonella typhimurium microorganisms using the MIC method. Although compound1 was found not to have a remarkable toxic effect at a concentration lower than 300 μg/mL, cytotoxic activity tests demonstrated that prosapogenin1a exhibits a significant cytotoxic activity against HeLa cell lines using the MTT assay for the first time. Abstract :