Apparent Carbon Monoxide Insertion via Double Isocyanide Incorporation during Palladium‐Catalyzed Construction of Indoloquinoline Ring in a Single Pot: Synthesis of New Cytotoxic Agents. Issue 21 (24th October 2016)

• Record Type: Journal Article
• Authors: Nallapati, Suresh Babu; Prasad, Bagineni; Sreenivas, B. Yogi; Sunke, Rajnikanth; Poornachandra, Y.; Kumar, C. Ganesh; Sridhar, B.; Shivashankar, S.; Mukkanti, K.; Pal, Manojit
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 21(2016)
• Page Start: 3387
• Page End: 3393
• Publication Date: 2016-10-24
• Subjects: amides -- cytotoxic agents -- indoloquinolines -- isocyanides -- palladium; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600599
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The formation of an amide bond via incorporation of two isocyanide units during a palladium‐catalyzed construction of the indoloquinoline ring afforded N ‐substituted 6 H ‐indolo[2, 3‐ b ]quinoline‐11‐carboxamides as new cytotoxic agents. The solvent and base play a key role in the selective and unprecedented synthesis of this class of amides. Abstract :