Breast Cancer Therapy: Defined Host–Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer (Small 42/2016). Issue 42 (7th November 2016)

• Record Type: Journal Article
• Authors: Ostadhossein, Fatemeh; Misra, Santosh K.; Mukherjee, Prabuddha; Ostadhossein, Alireza; Daza, Enrique; Tiwari, Saumya; Mittal, Shachi; Gryka, Mark C.; Bhargava, Rohit; Pan, Dipanjan
• Is Part Of: Small. Volume 12:Issue 42(2016)
• Page Start: 5782
• Page End: 5782
• Publication Date: 2016-11-07
• Subjects: breast cancer -- host–guest chemistry -- nanoparticles -- STAT‐3 -- vibrational spectroscopic imaging; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201670216
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : A theranostic, enzymatically biodegradable nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT‐3 inhibitor. On page 5845, D. Pan and co‐workers reveal that, overall, the supramolecular chemistry on nanocarbon acts as a novel arsenal for STAT‐3 inhibition in vitro and in vivo and provides signature intracellular tracking.