Intersubject variability and induced gamma in the visual cortex: DCM with empirical Bayes and neural fields. Issue 12 (4th September 2016)

• Record Type: Journal Article
• Authors: Pinotsis, Dimitris A.; Perry, Gavin; Litvak, Vladimir; Singh, Krish D.; Friston, Karl J.
• Is Part Of: Human brain mapping. Volume 37:Issue 12(2016:Dec.)
• Page Start: 4597
• Page End: 4614
• Publication Date: 2016-09-04
• Subjects: empirical Bayes -- random effects -- dynamic causal modeling -- neural fields -- classification -- Bayesian model reduction -- gamma oscillations; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.23331
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: This article describes the first application of a generic (empirical) Bayesian analysis of between‐subject effects in the dynamic causal modeling (DCM) of electrophysiological (MEG) data. It shows that (i) non‐invasive (MEG) data can be used to characterize subject‐specific differences in cortical microcircuitry and (ii) presents a validation of DCM with neural fields that exploits intersubject variability in gamma oscillations. We find that intersubject variability in visually induced gamma responses reflects changes in the excitation‐inhibition balance in a canonical cortical circuit. Crucially, this variability can be explained by subject‐specific differences in intrinsic connections to and from inhibitory interneurons that form a pyramidal‐interneuron gamma network. Our approach uses Bayesian model reduction to evaluate the evidence for (large sets of) nested models—and optimize the corresponding connectivity estimates at the within and between‐subject level. We also consider Bayesian cross‐validation to obtain predictive estimates for gamma‐response phenotypes, using a leave‐one‐out procedure. Hum Brain Mapp 37:4597–4614, 2016 . ©The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.