Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: a pilot cross-over study. (2nd January 2016)

• Record Type: Journal Article
• Authors: Kent, Katherine; Charlton, Karen E.; Jenner, Andrew; Roodenrys, Steven
• Is Part Of: International journal of food sciences and nutrition. Volume 67:Number 1(2016)
• Page Start: 47
• Page End: 52
• Publication Date: 2016-01-02
• Subjects: Acute -- anthocyanins -- blood pressure -- cherry juice -- cross-over -- dose; Food -- Analysis -- Periodicals; Nutrition -- Periodicals; 641.3
• DOI: 10.3109/09637486.2015.1121472
• Languages: English
• ISSNs: 0963-7486

Abstract

Abstract: A pilot cross-over study assessed the acute effects on blood pressure and plasma biomarkers associated with consumption of a 300 ml anthocyanin-rich fruit juice, provided in differing dose-intervals. Young adults ( n = 6) and older adults ( n = 7) received in random order, either a single 300 ml dose or 3 × 100 ml doses of high-flavonoid cherry juice provided at 0, 1 and 2 h. Blood pressure and plasma levels of phenolic metabolites were measured at 0, 2 and 6 h.The single 300 ml dose of cherry juice resulted in a significant reduction in systolic ( p = 0.002), and diastolic blood pressure ( p = 0.008) and heart-rate ( p = 0.033) 2 h after consumption, before returning to baseline levels at 6 h post-consumption. The 3 × 100 ml dose provided over 2 h did not result in significant blood pressure reductions. Plasma phenolic metabolites increased at 2 and 6 h; however, fluctuations were higher after the single 300 ml dose in older adults. These findings have implications for design of intervention studies that investigate vascular effects associated with flavonoid-rich foods.