Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer. (January 2017)

• Record Type: Journal Article
• Authors: He, Yu-Jing; Xing, Lei; Cui, Peng-Fei; Zhang, Jia-Liang; Zhu, Yong; Qiao, Jian-Bin; Lyu, Jin-Yuan; Zhang, Mei; Luo, Cheng-Qiong; Zhou, Yu-Xin; Lu, Na; Jiang, Hu-Lin
• Is Part Of: Biomaterials. Volume 113(2017)
• Page Start: 266
• Page End: 278
• Publication Date: 2017-01
• Subjects: Multidrug resistance -- pH-responsive -- Coordination bond -- Transferrin-inspired nanoparticles -- Doxorubicin; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2016.11.001
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: A novel biomimetic drug delivery system (BDDS) inspired by the pH-dependent ferric ion-transport and release manner of transferrin (Tf) was developed for combating multidrug-resistant breast cancer. Tf-inspired carrier was synthesized by modifying bovine serum albumin (BSA) with histamine (HA) through amide reaction to provide superior specific coordination sites for ferric ion-drug complexes, and self-assembled into nanoparticles (NPs) induced by coordination bond. Tf-inspired NPs were prepared via environment-friendly method, and well redispersed in saline after lyophilization. When internalized into tumor cells by SPARC (secreted protein acidic and rich in cysteine) mediated endocytosis, Tf-inspired NPs bypassed and decreased the P-glycoprotein-mediated drug efflux and led to more effective treatment of multidrug-resistant breast cancer compared with free drugs both in vitro and in vivo due to the enhanced cellular uptake and rapid pH-responsive drug release. Moreover, Tf-inspired NPs exhibited good biocompatibility and low systemic toxicity. Thus, our results demonstrate that Tf-inspired NPs based on coordination bond represent as a smart drug delivery strategy to combat multidrug-resistant cancer and have great potential for clinical applications in cancer therapy.