Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans. Issue 104 (27th October 2016)

• Record Type: Journal Article
• Authors: Gangar, Mukesh; Ittuveetil, Avinash; Goyal, Sandeep; Pal, Anang; Harikrishnan M., ; Nair, Vipin A.
• Is Part Of: RSC advances. Volume 6:Issue 104(2016)
• Page Start: 102116
• Page End: 102126
• Publication Date: 2016-10-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra22026f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The anti selective glycolate aldol reactions of ( S )-4-isopropyl-1-[( R )-1-phenylethyl]imidazolidin-2-one auxiliary have been standardized with high yields and excellent diastereoselectivities on various substituted aryl, allyl and alkyl aldehydes. Abstract : The anti selective glycolate aldol reactions of ( S )-4-isopropyl-1-[( R )-1-phenylethyl]imidazolidin-2-one auxiliary have been standardized with high yields and excellent diastereoselectivities on various substituted aryl, allyl and alkyl aldehydes. The optimized reaction conditions were employed for the stereoselective synthesis of oxyneolignans.