Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion. Issue 11 (November 2016)

• Record Type: Journal Article
• Authors: Mudit, Mudit; El Sayed, Khalid A.
• Is Part Of: Drug discovery today. Volume 21:Issue 11(2016)
• Page Start: 1745
• Page End: 1760
• Publication Date: 2016-11
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2016.06.032
• Languages: English
• ISSNs: 1359-6446

Abstract

Graphical abstract: Highlights: Modern drug discovery efforts are leaning toward natural product-based scaffolds. Marine natural products exemplify novel resources for new drugs. Marine organisms offer architecturally complex and unique structural features. Several MNPs can effectively target cancer cell migration and invasion. Abstract : The marine environment is a reliable source for the discovery of novel treatment options for numerous diseases. Past research efforts toward the discovery of marine-derived anticancer agents have resulted in several commercially available marine-based drugs. The pharmaceutical value of anticancer drugs from marine natural products (MNPs) ranges from US$563 billion to US$5.69 trillion. In this review, we highlight several marine-derived entities with the potential for cancer control and prevention through the inhibition of crucial tumor cell motility and/or migration steps involved in subsequent cancer metastases. This report also covers the major hurdles typically faced by the MNPs research scientific community. Teaser: Greater emphasis on marine natural products research could selectively cure multiple human ailments with fewer hazardous effects.