Cytomegalovirus antibody and vascular pathology in renal transplant recipients. Issue 1 (24th June 2016)

• Record Type: Journal Article
• Authors: Price, Patricia; Lee, Silvia; Affandi, Jacquita; Parsons, Richard; Naylor, Louise H.; Watts, Gerald F.; Irish, Ashley
• Is Part Of: Journal of medical virology. Volume 89:Issue 1(2017)
• Page Start: 177
• Page End: 181
• Publication Date: 2016-06-24
• Subjects: cytomegalovirus -- cardiovascular disease -- renal transplantation -- aging; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.24602
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls ( P < 0.001), and correlated with vascular endothelial function measured by flow mediated‐dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect ( P = 0.068), with age ( P = 0.013), gender ( P < 0.0001), and transplantation ( P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177–181, 2017 . © 2016 Wiley Periodicals, Inc.