Pharmacokinetic indices for cefovecin after single‐dose administration to adult sea otters (Enhydra lutris). Issue 6 (22nd May 2016)

• Record Type: Journal Article
• Authors: Lee, E. A.; Byrne, B. A.; Young, M. A.; Murray, M.; Miller, M. A.; Tell, L. A.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 39:Issue 6(2016)
• Page Start: 625
• Page End: 628
• Publication Date: 2016-05-22
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12322
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract : Seven sea otters received a single subcutaneous dose of cefovecin at 8 mg/kg body weight. Plasma samples were collected at predetermined time points and assayed for total cefovecin concentrations using ultra‐performance liquid chromatography and tandem mass spectrometry. The mean (±SD) noncompartmental pharmacokinetic indices were as follows: C Max (obs) 70.6 ± 14.6 μg/mL, T Max (obs) 2.9 ± 1.5 h, elimination rate constant ( k el ) 0.017 ± 0.002/h, elimination half‐life ( t 1/2 k el) 41.6 ± 4.7 h, area under the plasma concentration‐vs.‐time curve to last sample (AUClast) 3438.7 ± 437.7 h·μg/mL and AUC extrapolated to infinity (AUC0→∞ ) 3447.8 ± 439.0 h·μg/mL. The minimum inhibitory concentrations (MIC) for select isolates were determined and used to suggest possible dosing intervals of 10 days, 5 days, and 2.5 days for gram‐positive, gram‐negative, and Vibrio parahaemolyticus bacterial species, respectively. This study found a single subcutaneous dose of cefovecin sodium in sea otters to be clinically safe and a viable option for long‐acting antimicrobial therapy.