Decarboxylative Aminomethylation of Aryl‐ and Vinylsulfonates through Combined Nickel‐ and Photoredox‐Catalyzed Cross‐Coupling. Issue 46 (10th October 2016)

• Record Type: Journal Article
• Authors: Fan, Lulu; Jia, Jiaqi; Hou, Hong; Lefebvre, Quentin; Rueping, Magnus
• Is Part Of: Chemistry. Volume 22:Issue 46(2016)
• Page Start: 16437
• Page End: 16440
• Publication Date: 2016-10-10
• Subjects: amino acids -- cross-coupling -- decarboxylation -- nickel catalysis -- photoredox catalysis; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201604452
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A mild approach for the decarboxylative aminomethylation of aryl sulfonates by the combination of photoredox and nickel catalysis through C−O bond cleavage is described for the first time. A wide range of aryl triflates as well as aryl mesylates, tosylates and alkenyl triflates afford the corresponding products in good to excellent yields. Abstract : A mild approach for the decarboxylative aminomethylation of aryl sulfonates by the combination of photoredox and nickel catalysis through C−O bond cleavage is described. A variety of aryl triflates, mesylates, tosylates, and alkenyl triflates react with α‐amino acids to afford the corresponding aminomethylated products in good to excellent yields.