MMP-2 gene polymorphisms are associated with type A aortic dissection and aortic diameters in patients. Issue 42 (October 2016)

• Record Type: Journal Article
• Authors: Liu, Ou; Xie, Wuxiang; Qin, Yanwen; Jia, Lixin; Zhang, Jing; Xin, Yi; Guan, Xinliang; Li, Haiyang; Gong, Ming; Liu, Yuyong; Wang, Xiaolong; Li, Jianrong; Lan, Feng; Zhang, Hongjia
• Other Names: Tarantino. Giovanni section editor.
• Is Part Of: Medicine. Volume 95:Issue 42(2016)
• Publication Date: 2016-10
• Subjects: aortic diameter -- MMP-2 gene -- single nucleotide polymorphism -- type A aortic dissection; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000005175
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Matrix metalloproteinases-2 (MMP-2) plays an important role in the pathogenesis of type A aortic dissection (AD). The aim of this study was to evaluate the association of 3 single nucleotide polymorphisms (SNPs) in the MMP-2 gene with type A AD risk and aortic diameters in patients. We performed a case–control study with 172 unrelated type A AD patients and 439 controls. Three SNPs rs11644561, rs11643630, and rs243865 were genotyped through the MassARRAY platform. Allelic associations of SNPs and SNP haplotypes with type A AD and aortic diameters in patients were evaluated. The frequency of the G allele of the rs11643630 polymorphism was significantly lower in type A AD patients than in control subjects (odds ratio 0.705, 95% confidence interval 0.545–0.912, P = 0.008). The association remained significant after adjusting for clinical covariates ( P = 0.008). Carriers of the GG genotype of the rs11643630 polymorphism had significantly smaller aortic diameters than those with GT genotype or TT genotype ( P = 0.02). Further haplotype analysis identified 1 protective haplotype (GC; P = 0.008) for development of type A AD. Again, a significant correlation was observed between haplotype GC and AD size ( P = 0.020). Our results suggest that MMP-2 gene polymorphisms contribute to type A AD susceptibility. In addition, MMP-2 gene SNPs are associated with AD size, which could be used as a target for the development of new drug therapy.