Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats. Issue 24 (16th December 2016)

• Record Type: Journal Article
• Authors: Cristani, M.; Speciale, A.; Mancari, F.; Arcoraci, T.; Ferrari, D.; Fratantonio, D.; Saija, A.; Cimino, F.; Trombetta, D.
• Is Part Of: Natural product research. Volume 30:Issue 24(2016)
• Page Start: 2845
• Page End: 2849
• Publication Date: 2016-12-16
• Subjects: Acetaminophen -- hepatoprotection -- anthocyanin -- oxidative stress -- biomarkers; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1160235
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract. Abstract :