Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII. Issue 1 (1st January 2017)

• Record Type: Journal Article
• Authors: Esirden, İbrahim; Tanç, Muhammet; Supuran, Claudiu T.; Kaya, Muharrem
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 1(2017)
• Page Start: 86
• Page End: 89
• Publication Date: 2017-01-01
• Subjects: Tetrazole -- Sulfonamide -- Octahydroacridine -- Chromene -- Carbonic anhydrase -- Enzyme inhibition; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.11.028
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: Synthesis tetrazoles/sulfonamides conjugate octahydroacridine, xanthene, chromene. Characterization of compounds with FT-IR, 1H NMR, 13C NMR (APT), HRMS. The synthesized new compounds have potential interesting biological properties. The inhibition profile investigated against hCA I, II, IV and VII isoforms. Noticeable inhibition profile of octahydroacridine conjugate sulfonamides. Abstract: The synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene scaffold by using microwave (MW) assisted techniques is reported in this study. These synthesized hybrid compounds were assayed for the inhibition of carbonic anhydrase (CA, EC 4.2.1.1). The inhibitory activities were determined against three cytosolic human isoforms (hCA I, II and VII) and one membrane-associated (hCA IV) isoform. Some of the newly synthesized sulfonamides showed micromolar to nanomolar inhibitory activity against these enzymes.