[18F]-FDG PET neuroimaging in rats with quinpirole-induced checking behavior as a model for obsessive compulsive disorder. (30th November 2016)

• Record Type: Journal Article
• Authors: Servaes, Stijn; Glorie, Dorien; Verhaeghe, Jeroen; wyffels, Leonie; Stroobants, Sigrid; Staelens, Steven
• Is Part Of: Psychiatry research. Volume 257(2016)
• Page Start: 31
• Page End: 38
• Publication Date: 2016-11-30
• Subjects: Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2016.10.003
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: Chronic quinpirole led to increased locomotor activity and frequency of visits. Acute exposure increased while chronic exposure to quinpirole decreased the total glucose consumption in the brain. Acute administration increased the local cerebral glucose uptake in regions with poor direct connection to the dopaminergic system. Strong reductions after chronic exposure were seen in the cortico-striato-thalamico-cortical circuit. Alterations in (para)limbic regions indicates a more extensive disease mechanism.