SREBF-2 polymorphism influences white matter microstructure in bipolar disorder. (30th November 2016)

• Record Type: Journal Article
• Authors: Poletti, Sara; Aggio, Veronica; Bollettini, Irene; Falini, Andrea; Colombo, Cristina; Benedetti, Francesco
• Is Part Of: Psychiatry research. Volume 257(2016)
• Page Start: 39
• Page End: 46
• Publication Date: 2016-11-30
• Subjects: Sterol regulatory element binding protein -- White matter -- Myelination -- Cholesterol -- Bipolar disorder; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2016.10.001
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: The aim of the study is to investigate if gene polymorphisms in sterol regulatory element binding protein transcriptional factors SREBF-1 and SREBF-2, which regulate lipid and cholesterol metabolism, could affect white matter (WM) microstructure, the most recognized structural biomarker of bipolar disorder (BD). In a sample of 93 patients affected by BD, we investigated the effect of SREBF-1 rs11868035, and SREBF-2 rs1052717, on WM microstructure, using diffusion tensor imaging and tract-based spatial statistics. We observed increased radial diffusivity in the rs1052717 A/A genotype compared to A/G and G/G, and reduced fractional anisotropy (FA) in the rs1052717 A/A genotype compared to G carriers in cingulum, corpus callosum, superior and inferior longitudinal fasciculi, and anterior thalamic radiation. These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in BD and therefore a possible role of SREBP pathway in CNS myelination processes. Highlights: rs1052717 polymorphism influence measures of white matter integrity in BD. rs11868035 is not associated with measures of white matter integrity in BD. SREBF-2 polymorphism seems to influence white matter microstructure in BD. SREBP pathway could play a role in CNS myelination processes.