Calcium(II) catalyzed regioselective dehydrative cross-coupling reactions: Practical synthesis of internal alkenes and benzopyrans. Issue 52 (28th December 2016)

• Record Type: Journal Article
• Authors: Yaragorla, Srinivasarao; Pareek, Abhishek; Dada, Ravikrishna; Almansour, Abdulrahman I.; Arumugam, Natarajan
• Is Part Of: Tetrahedron letters. Volume 57:Issue 52(2016)
• Page Start: 5841
• Page End: 5845
• Publication Date: 2016-12-28
• Subjects: Dehydrative cross coupling reaction -- Calcium catalysis -- Internal alkenes -- Benzopyrans -- Green synthesis -- Cascade synthesis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.11.027
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Highly versatile and regioselective method for the synthesis of internal alkenes. Unique method for dehydrative cross-coupling/homo-dimerization/direct cross couplings. Successfully extended to the synthesis of novel benzopyrans. Solvent-free; step, atom economy and environmentally benign catalyst. Large substrate scope, high yields; user-friendly protocol. Abstract: A simple and operationally easy protocol for the regioselective synthesis of internal alkenes through a dehydrative cross-coupling and direct coupling procedure has been described using the environmentally benign Ca(II) catalyst. Several alkenes and alcohols underwent the coupling reaction under solvent-free conditions in a short time to produce the desired alkenes. This method is further extended to show the application in the synthesis of novel benzopyran molecules through a cascade strategy.