Neuroprotective effects of hypothermia in inflammatory-sensitized hypoxic-ischemic encephalopathy. Issue 55 (December 2016)

• Record Type: Journal Article
• Authors: Chevin, Mathilde; Guiraut, Clémence; Maurice-Gelinas, Caroline; Deslauriers, Jessica; Grignon, Sylvain; Sébire, Guillaume
• Is Part Of: International journal of developmental neuroscience. Issue 55(2016:Dec.)
• Page Start: 1
• Page End: 8
• Publication Date: 2016-12
• Subjects: Neonatal encephalopathy -- Inflammation -- Hypothermia -- Neuroprotection; Developmental neurobiology -- Periodicals; Neurology -- Periodicals; Neurologie du développement -- Périodiques; Developmental neurobiology; Periodicals; 612.8
• DOI: 10.1016/j.ijdevneu.2016.09.002
• Languages: English
• ISSNs: 0736-5748

Abstract

Highlights: HT is neuroprotective against inflammatory-sensitized HI. HT increases antioxidant enzymes, responsible for clearing reactive oxygen species. The beneficial effect of HT is not mediated by modulation of the IL-1 system. Abstract: Background: Despite the recent introduction of hypothermia as a mandatory standard of care, the incidence of neonatal encephalopathy in full-term newborns and its devastating neuro-behavioral outcomes continues to be a major individual, familial and social issue. Neonatal encephalopathy is mainly due to the compounding and interacting effects of hypoxia-ischemia and inflammation resulting from placental and other perinatal infections. It is unclear why hypothermia is effective in alleviating neonatal encephalopathy in some, but not all, full-term newborns. However, newborns exposed to inflammatory-sensitized hypoxia-ischemia seem to have less therapeutic benefit from hypothermia than those exposed to hypoxia-ischemia alone. Objectives: To clarify this uncertainty, we tested the efficacy of hypothermia in a double-hit model of neonatal encephalopathy induced by inflammatory-sensitized hypoxia-ischemia. Methods: Using a rat preclinical model of endotoxin plus hypoxia-ischemia-induced neonatal encephalopathy of term newborns, we assessed the following in pups exposed (or not) to hypothermia: the extent of brain injuries and the expressions of molecules implicated in neural cell death, namely: pro-inflammatory cytokines, matrix metalloproteinase-9, antioxidant enzymes, as well as receptor-interacting protein-3. Results: Hypothermia was neuroprotective on inflammatory-sensitized hypoxia-ischemia-induced penumbra, but not core, brain injuries. This beneficial effect was associated with a hypothermia-induced increase of antioxidant enzymes (superoxide dismutase-1, glutathione peroxidase-1), but was not associated with any variations of the other inflammatory mediators tested, namely: interleukin-1β, interleukin-1 receptor antagonist, tumor necrosis factor-α and matrix metalloproteinase-9. Conclusion: Hypothermia is neuroprotective against inflammatory-sensitized hypoxia-ischemia possibly through a hypothermia-induced increase of antioxidant enzymes. This neuroprotective effect seems to be independent of the interleukin-1 system.