CA19-9-Low&Lewis (+) pancreatic cancer: A unique subtype. (28th January 2017)
- Record Type:
- Journal Article
- Title:
- CA19-9-Low&Lewis (+) pancreatic cancer: A unique subtype. (28th January 2017)
- Main Title:
- CA19-9-Low&Lewis (+) pancreatic cancer: A unique subtype
- Authors:
- Luo, Guopei
Liu, Chen
Guo, Meng
Long, Jiang
Liu, Zuqiang
Xiao, Zhiwen
Jin, Kaizhou
Cheng, He
Lu, Yu
Ni, Quanxing
Yu, Xianjun - Abstract:
- Abstract: The study was performed to identify unique subtype from the long-term survival (>24 months) patients with advanced pancreatic cancer (1039 cases). Long-term survival patients had higher proportion of low secretion of carbohydrate antigen 19-9 (CA19-9) than that of patients with non long-term survival (P < 0.001). Considering the impact of Lewis status on CA19-9 secretion, Lewis genotypes were further determined by Sanger sequencing. The prognosis of CA19-9-Low&Lewis (−) patients was worse than that of CA19-9-Low&Lewis (+) (hazard ratio (HR) = 0.37, P < 0.001). The proportion of epidermal growth factor receptor (EGFR) (−) cases was lower in the CA19-9-Low&Lewis (+) subgroup than that in other patients (P = 0.047). For the CA19-9-Low&Lewis (+) subgroup, chemotherapy plus radiotherapy but not chemotherapy was found to be an independent prognostic factor (versus best supportive care, chemotherapy, HR = 0.71, P = 0.267; chemotherapy plus radiotherapy, HR = 0.33, P = 0.022). We conclude that CA19-9-Low&Lewis (+) pancreatic cancer is a unique subtype with special biological properties. Highlights: Long-term survival patients had higher proportion of CA19-9 low-secretion (CA19-9 normal) than that of patients with non long-term survival. The prognosis of CA19-9-Low&Lewis (−) patients was worse than that of CA19-9-Low&Lewis (+). For the CA19-9-Low&Lewis (+) subgroup, chemotherapy plus radiotherapy but not chemotherapy was found to be an independent prognostic factor.
- Is Part Of:
- Cancer letters. Volume 385(2017)
- Journal:
- Cancer letters
- Issue:
- Volume 385(2017)
- Issue Display:
- Volume 385, Issue 2017 (2017)
- Year:
- 2017
- Volume:
- 385
- Issue:
- 2017
- Issue Sort Value:
- 2017-0385-2017-0000
- Page Start:
- 46
- Page End:
- 50
- Publication Date:
- 2017-01-28
- Subjects:
- Pancreatic adenocarcinoma -- Lewis antigen -- Heterogeneity -- CA19-9
Cancer -- Periodicals
Neoplasms -- Periodicals
Cancer -- Périodiques
Electronic journals
616.994 - Journal URLs:
- http://www.sciencedirect.com/science/journal/03043835/ ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.canlet.2016.10.046 ↗
- Languages:
- English
- ISSNs:
- 0304-3835
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3046.485000
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