Infection of human uterine fibroblasts by Zika virus in vitro: implications for viral transmission in women. (October 2016)

• Record Type: Journal Article
• Authors: Chen, Joseph C.; Wang, Zuguang; Huang, Hong; Weitz, Sara H.; Wang, Aprilgate; Qiu, Xiaolei; Baumeister, Mark A.; Uzgiris, Arejas
• Is Part Of: International journal of infectious diseases. Volume 51(2016:Oct.)
• Page Start: 139
• Page End: 140
• Publication Date: 2016-10
• Subjects: Zika virus -- Uterine fibroblasts -- Heterosexual transmission -- Viral detection -- Women's health; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2016.07.015
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Human uterine fibroblasts are susceptible to Zika virus infection. Both African and Puerto Rican Zika strains can infect human uterine fibroblasts. A quantitative reverse transcription PCR with primers targeting the envelop regions of the virus was utilized. Uterine fibroblasts continually produced virus, while maintaining cellular viability over 5 days. Uterine fibroblasts may be linked with heterosexual transmission of Zika virus in women.