Boundary propagation of planar cell polarity is robust against cell packing pattern. (7th December 2016)

• Record Type: Journal Article
• Authors: Yamashita, Satoshi; Michiue, Tatsuo
• Is Part Of: Journal of theoretical biology. Volume 410(2016)
• Page Start: 44
• Page End: 54
• Publication Date: 2016-12-07
• Subjects: Multi-polarity -- Mathematical model -- Simulation; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2016.09.011
• Languages: English
• ISSNs: 0022-5193

Abstract

Abstract: Planar cell polarity is an important property of epithelial tissue. The boundary propagation model was proposed as the mechanism of PCP induction, while it has been doubted whether it can induce PCP on wide tissue. Using simulation, a set of proteins can be shown to induce PCP, but it does not explain why and how the set can induce PCP. In this study, we made theoretical model and simulation model to explore when and how the boundary propagation induce PCP. We incorporated multipolar cell in our model. Intracellular interactions have been thought to amplify polarity of a cell, but we propose instead that they are to keep a cell-cell interface polarized, and bipolarity of cell is obtained as a result. We show that the boundary propagation can propagate polarity as long as average size of local cell group is constant and levels of PCP proteins are balanced in every cell. Therefore, this model provide an explanation for PCP induction on a tissue with multiple cell types. Abstract : Highlights: Boundary propagation is capable of long-range PCP induction. Proteins expression levels must be balanced inside every cell. PCP is equivalent to order relation among cells with cell-cell interface polarity. Cells of any type or size must be distributed evenly across a tissue.