Cost-effectiveness of obinutuzumab for chronic lymphocytic leukaemia in The Netherlands. (November 2016)

• Record Type: Journal Article
• Authors: Blommestein, Hedwig M.; de Groot, Saskia; Aarts, Mieke J.; Vemer, Pepijn; de Vries, Robin; van Abeelen, Annet F.M.; Posthuma, E.F.M. Ward; Uyl-de Groot, Carin A.
• Is Part Of: Leukemia research. Volume 50(2016:Nov.)
• Page Start: 37
• Page End: 45
• Publication Date: 2016-11
• Subjects: ICER incremental cost-effectiveness ratio -- QALY quality-adjusted life-year -- ITC indirect treatment comparison; Chronic lymphocytic leukaemia -- Obinutuzumab -- Chlorambucil -- Rituximab -- Ofatumumab -- Cost-effectiveness -- Costs; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2016.09.005
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: GClb appeared to be a cost-effective treatment strategy compared to RClb and Clb. The ICERs of GClb compared to RClb and Clb were €23, 208 and €7254 per QALY. Indirect treatment comparisons showed favourable ICERs for GClb compared to OClb. The ICERs of GClb compared to OClb varied from €6556 to €16, 180 per QALY. Abstract: Background: Obinutuzumab combined with chlorambucil (GClb) has shown to be superior to rituximab combined with chlorambucil (RClb) and chlorambucil (Clb) in newly diagnosed patients with chronic lymphocytic leukaemia (CLL). This study evaluates the cost-effectiveness per life-year and quality-adjusted life-year (QALY) of GClb compared to RClb, Clb, and ofatumumab plus chlorambucil (OClb) in The Netherlands. Methods: A Markov model was developed to assess the cost-effectiveness of GClb, RClb, Clb and other treatments in the United Kingdom. A country adaptation was made to estimate the cost-effectiveness of these therapies in The Netherlands using Dutch unit costs and Dutch data sources for background mortality and post-progression survival. Results: An incremental gain of 1.06 and 0.64 QALYs was estimated for GClb compared to Clb and RClb respectively, at additional costs of €23, 208 and €7254 per patient. Corresponding incremental cost-effectiveness ratios (ICERs) were €21, 823 and €11, 344 per QALY. Indirect treatment comparisons showed an incremental gain varying from 0.44 to 0.77 QALYs for GClb compared to OClb and additional costs varying from €7041 to €5028 per patient. The ICER varied from €6556 to €16, 180 per QALY. Sensitivity analyses showed the robustness of the results. Conclusion: GClb appeared to be a cost-effective treatment strategy compared to RClb, OClb and Clb.