Association between ambient particulate matter exposure and semen quality in Wuhan, China. (January 2017)

• Record Type: Journal Article
• Authors: Wu, Li; Jin, Lei; Shi, Tingming; Zhang, Bing; Zhou, Yun; Zhou, Ting; Bao, Wei; Xiang, Hua; Zuo, Yao; Li, Guanlian; Wang, Cheng; Duan, Yonggang; Peng, Zhe; Huang, Xiji; Zhang, Hai; Xu, Tian; Li, Yonggang; Pan, Xinyun; Xia, Ying; Gong, Xun; Chen, Weihong; Liu, Yuewei
• Is Part Of: Environment international. Volume 98(2017:Jan.)
• Page Start: 219
• Page End: 228
• Publication Date: 2017-01
• Subjects: Air pollution -- Particulate matter -- Semen quality -- Sperm concentration -- Exposure-response relation; PM2.5 particulate matter < 2.5 μm in aerodynamic diameter -- PM10 particulate matter < 10 μm in aerodynamic diameter -- IDW inverse distance weighting -- WHO World Health Organization -- AQI air quality index -- BMI body mass index -- SD standardized deviation -- 95% CI 95% confidence interval -- IQR interquartile range -- df degree of freedom -- FDR false discovery rate -- ROS reactive oxygen species; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2016.11.013
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Health effects of exposure to particulate matter (PM) on male reproductive health remain unclear. Only a limited number of studies have investigated the effects of PM2.5 or PM10 exposure on semen quality, and the results were largely inconsistent. Objectives: To quantitatively assess the exposure-response association between PM exposure and semen quality in Chinese men who were exposed to a wide concentration range of PM. Methods: We investigated 1759 men from Wuhan, China, who were partners of women undergoing assisted reproductive technology procedures, and had semen examined at least once between 2013 and 2015. Individual PM2.5 and PM10 exposures during 0–90, 0–9, 10–14 and 70–90 days before each semen examination (corresponding to the entire and three key periods of sperm development, respectively) were retrospectively estimated by inverse distance weighting interpolation. Linear mixed models were used to assess exposure-response relations of PM exposure with sperm concentration, count and motility. Results: PM2.5 exposure during 0–90 lag days ranged from 27.3 to 172.4 μg/m 3 . It was linearly and inversely associated with sperm concentration (β: −0.20; 95% CI: −0.34, −0.07) and count (−0.22; −0.35, −0.08). For the three key exposure periods, only PM2.5 exposure during the 70–90 lag days was significantly associated with sperm concentration (−0.12; −0.22, −0.03) and count (−0.12; −0.21, −0.02). Sensitivity analyses for a subgroup ( n = 1146) excluding subjects with abnormal sperm concentration, count or motility yielded similar results. Compared with PM2.5, we found generally similar associations for PM10 exposure in relation to sperm concentration and count, except that the associations appeared to be nonlinear with inverted J-shaped relationships. Neither PM2.5 nor PM10 exposure was significantly associated with sperm motility (all p &gt; 0.05). Conclusions: Our results suggest that ambient PM exposure during sperm development adversely affects semen quality, in particular sperm concentration and count. Highlights: We assessed the association between PM and semen quality among 1759 Chinese men. PM2.5 and PM10 exposures are associated with sperm concentration and count. PM exposures are unlikely to be associated with sperm motility. PM may decrease semen quality mainly by affecting spermatogenesis. Our study emphasizes the urgent needs to reduce PM exposure in China.