Determination and correlation of Avermectin B1a solubility in different binary solvent mixtures at temperatures from (283.15 to 313.15) K. (February 2017)

• Record Type: Journal Article
• Authors: Shen, Huan; Wu, Songgu; Liu, Yumin; Li, Kangli; Xu, Shijie; Gong, Junbo
• Is Part Of: Journal of chemical thermodynamics. Volume 105(2017)
• Page Start: 253
• Page End: 266
• Publication Date: 2017-02
• Subjects: Avermectin B1a -- Solubility -- Binary solvent mixtures -- Thermodynamic model -- Thermodynamic properties; Thermodynamics -- Periodicals; Thermochemistry -- Periodicals; Thermodynamique -- Périodiques; Thermochimie -- Périodiques; Thermochemistry; Thermodynamics; Periodicals; 541.369
• DOI: 10.1016/j.jct.2016.10.022
• Languages: English
• ISSNs: 0021-9614

Abstract

Highlights: The solubility of Avermectin B1a in three binary mixtures was determined. The experimental solubility were correlated by three thermodynamic models. Thermodynamic properties of mixing of Avermectin B1a were calculated. Abstract: The solubility of Avermectin B1a (AVM B1a ) in the three binary solvent mixtures, (acetone + water), (acetone + n-hexane) and (isopropanol + n-hexane) was determined gravimetrically with the temperature ranging from 283.15 K to 313.15 K under atmospheric conditions. The experimental results indicate that the solubility of AVM B1a increased with increasing temperature at certain solvent composition, and decreased with increasing mole fraction of water and n-hexane. Besides, the modified Apelblat equation, CNIBS/R-K model and Jouyban-Acree model were employed to correlate the solubility results obtained. All the selected models provide satisfactory results. Furthermore, the mixing thermodynamic properties were calculated based on the NRTL equation, a binary activity coefficient model. We also calculated the thermodynamic properties of the dissolution process of AVM B1a . The calculated results indicate that the dissolution process of AVM B1a in the tested solvents is endothermic and spontaneous.