Association of serum bactericidal antibody and opsonic antibody levels after Neisseria meningitidis serogroup C conjugate vaccine in Brazilian children and adolescents infected or not infected with HIV. Issue 50 (7th December 2016)

• Record Type: Journal Article
• Authors: Pereira-Manfro, Wânia F.; Alvino, Raquel M.; Cruz, Aline C.; Silva, Giselle P.; Castro, Raquel B.N.; Ferreira, Bianca; Barreto, Daniella M.; Frota, Ana Cristina C.; Hofer, Cristina B.; Milagres, Lucimar G.
• Is Part Of: Vaccine. Volume 34:Issue 50(2016)
• Page Start: 6116
• Page End: 6119
• Publication Date: 2016-12-07
• Subjects: C-PS C-polysaccharide -- FSC forward scatter -- HEU HIV-exposed but uninfected children group -- MenC Neisseria meningitidis serogroup C -- OPA opsonic antibody -- PBS phosphate buffer saline -- PMN Polymorphonuclear cells -- SBA bactericidal antibody -- SSC side scatter -- V1 before immunization -- V2 one-two months after first dose -- V3 one year after first dose -- V4 one-two months after booster; Neisseria meningitidis C -- Meningococcal conjugate vaccine -- Opsonic antibodies -- Bactericidal antibodies -- HIV; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2016.11.011
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Neisseria meningitidis serogroup C (MenC) is the main causative agent of meningitis in Brazil. HIV infection affects the quality of the immune system. HIV + children have an increased risk of infection to encapsulated bacteria such as N. meningitidis . We evaluated the opsonic antibody (OPA) levels and its correlation with serum bactericidal antibody (SBA) levels induced by one and two doses of a MenC conjugate vaccine in children and adolescents HIV + and HIV-exposed but uninfected children (HEU) group. Overall the data show the importance of two doses of vaccine for HIV + individuals. About 79% and 58% of HIV + patients showed SBA and OPA positive response after two doses of vaccine, respectively. For HEU group, 62% and 41% of patients showed SBA and OPA positive response after one dose of vaccine, respectively. A positive and significant association between SBA and OPA levels was seen after two doses of vaccine in HIV + patients.