Periconiasins I and J, two new cytochalasans from an endophytic fungus Periconia sp. Issue 51 (21st December 2016)

• Record Type: Journal Article
• Authors: Liu, Jimei; Zhang, Dewu; Zhang, Min; Liu, Xia; Chen, Ridao; Zhao, Jinlian; Li, Li; Wang, Nan; Dai, Jungui
• Is Part Of: Tetrahedron letters. Volume 57:Issue 51(2016)
• Page Start: 5794
• Page End: 5797
• Publication Date: 2016-12-21
• Subjects: Periconia sp. -- Endophytic fungus -- Cytochalasan -- Periconiasin; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.11.038
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Two new cytochalasans, periconiasins I and J were isolated from the endophytic fungus Periconia sp. F-31. Periconiasins I features 9/6/5 tricyclic ring and exhibited cytotoxicity against human MCF-7 tumor cells. Periconiasins J possesses 5/6/6/5 tetracyclic ring and displays anti-HIV activity. Abstract: Two new cytochalasans, periconiasin I (1 ) with 9/6/5 tricyclic ring, and periconiasin J (2 ) with 5/6/6/5 tetracyclic ring, were isolated from the endophytic fungus Periconia sp. F-31. Their structures including absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and the circular dichroism data of the [Rh2 (OCOCF3 )4 ] complex. Compound1 showed in vitro cytotoxicity against human MCF-7 tumor cell line with an IC50 value of 4.8 μM, compound2 exhibited weak anti-HIV activity with an IC50 value of 25.0 μM.