Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis. Issue 51 (21st December 2016)

• Record Type: Journal Article
• Authors: Chen, Xuyun; Yu, Yang; Liao, Ziyang; Li, Hao; Wang, Wei
• Is Part Of: Tetrahedron letters. Volume 57:Issue 51(2016)
• Page Start: 5742
• Page End: 5745
• Publication Date: 2016-12-21
• Subjects: Diarylyclopropane -- Enantioselective -- Organocatalysis -- Benzyl chloride -- Cinnamaldehyde; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.10.097
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Chiral trisubstituted diarylcyclopropanecarboaldehydes have been synthesized by organocatalysis. The enantioselectivities of trisubstituted diarylcyclopropanecarboaldehydes are very high. The reactions can be proceeded under the mild conditions. Abstract: An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α, β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.