Acephate exposure during a perinatal life program to type 2 diabetes. (30th November 2016)

• Record Type: Journal Article
• Authors: Ribeiro, Tatiane Aparecida; Prates, Kelly Valério; Pavanello, Audrei; Malta, Ananda; Tófolo, Laize Peron; Martins, Isabela Peixoto; Oliveira, Júlio Cezar de; Miranda, Rosiane Aparecida; Gomes, Rodrigo Mello; Vieira, Elaine; Franco, Claudinéia Conationi da Silva; Barella, Luiz Felipe; Francisco, Flávio Andrade; Alves, Vander Silva; Silveira, Sandra da Silva; Moreira, Veridiana Mota; Fabricio, Gabriel Sergio; Palma-Rigo, Kesia; Sloboda, Deborah M.; Mathias, Paulo Cezar de Freitas
• Is Part Of: Toxicology. Volume 372(2016)
• Page Start: 12
• Page End: 21
• Publication Date: 2016-11-30
• Subjects: ipGTT intraperitoneal glucose tolerance test -- ipITT intraperitoneal insulin tolerance test -- ivGTT intravenous glucose tolerance test -- ipPTT intraperitoneal pyruvate tolerance test -- BuChE butyrylcholinesterase -- DOHaD developmental origins of health and disease -- OP organophosphates -- COBEA Brazilian association for animal experimentation -- AChE acetylcholinesterase -- Ach acetylcholine -- ACE acephate -- AUC area under the curve -- P0 post, natal day 0 -- P21 post-natal day 21 -- P90 post-natal day 90 -- RIA radioimmunoassay -- Kitt constant for insulin tolerance test -- LOAEL lowest observed adverse effect level -- HDL high density lipoproteins -- VLDL very low density lipoproteins -- LDL low density lipoproteins; Acephate -- Pregnancy -- Lactation -- Glucose metabolism -- Lipid metabolism -- Offspring; Toxicology -- Periodicals; Chemicals -- Physiological effect -- Periodicals; 615.9005
• DOI: 10.1016/j.tox.2016.10.010
• Languages: English
• ISSNs: 0300-483X

Abstract

Abstract: Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring health-care costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes.