Elevated preoperative HMGB1 as predictor of myocardial injury post-percutaneous coronary intervention. Issue 46 (November 2016)

• Record Type: Journal Article
• Authors: Jin, Peng; Zhou, Qi; Song, Shujiang; Xu, Jinpeng; Zhang, Minli; Zhu, Ming; Kang, Meili; Shi, Xiangming; Shi, Junting; Lu, Di; Li, Jing
• Editors: Bil., Jacek
• Is Part Of: Medicine. Volume 95:Issue 46(2016)
• Page Start: e5149
• Publication Date: 2016-11
• Subjects: creatine kinase-MB -- high mobility group box1 -- myocardial injury -- percutaneous coronary intervention -- troponin I; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000005149
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention. We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperative HMGB1 levels. Creatine kinase-MB and troponin I levels were measured at baseline, 8- and 24-hours after the procedure, while clinical outcomes were followed up for 1 year. The occurrence of post-procedural myocardial injury was significantly higher in the tertile comprising of patients with elevated HMGB1 levels. Moreover, these patients showed significantly higher post-procedural peak values of creatine kinase-MB and troponin I in comparison to patients with lower HMGB1 levels. Event-free survival was significantly associated with HMGB1 levels, with worst event-free survival in patients with elevated HMGB1 levels. Elevated preoperative HMGB1 was a predictor of myocardial injury after percutaneous coronary intervention, and was associated with the worst clinical outcomes during 1-year follow up.