An electro-conductive fluid as a responsive implant for the controlled stimuli-release of diclofenac sodium. (2nd October 2016)

• Record Type: Journal Article
• Authors: Bijukumar, Divya; Choonara, Yahya E.; Kumar, Pradeep; du Toit, Lisa C.; Pillay, Viness
• Is Part Of: Pharmaceutical development and technology. Volume 21:Number 7(2016)
• Page Start: 875
• Page End: 886
• Publication Date: 2016-10-02
• Subjects: Diclofenac sodium -- electro-conductive fluid -- molecular mechanics simulations -- "ON–OFF" pulsatile drug release kinetics -- stimuli responsive implant; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2015.1073742
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: The purpose of this study was to develop an electro-responsive co-polymeric (ERP) implantable gel from polyethylene glycol (PEG), sodium polystyrene sulphonate (NaPss), polyvinyl alcohol (PVA), and diethyl acetomidomalonate (DAA) for electro-liberation of the model drug diclofenac sodium. Various physicochemical and physicomechanical characterization tests were undertaken on the synthesized drug-free gel (ERP G1) and drug-loaded gel (ERP G2). The ability of the gel to release diclofenac sodium following electrical stimulation was evaluated using a galvanostat while Molecular Mechanics (MM) simulations were performed to elucidate the experimental mechanisms. A stable electro-active gel exhibiting superior cycling stability was produced with desirable rheological properties, rigidity (BHN = 35.4 N ± 0.33 N/mm 2 ; resilience = 10.91 ± 0.11%), thermal properties ( T g ≈ 70 °C; T c ≈ 200 °C) and homogeneous morphology. "ON–OFF" pursatile gradual drug release (37–94% from t 30 min − t 180 min ) kinetics was observed upon applying electric stimulation intermittently, indicating that drug release from the gel was electrically controlled. Overall, the galvanometric and MM evaluation ascertained the suitability of the PEG/NaPss/PVA ERP-Gel for application as a subcutaneously injectable drug delivery implant.