Acute eosinophilic pneumonia caused by camostat mesilate: The first case report. (2016)

• Record Type: Journal Article
• Authors: Ota, Shinichiro; Hara, Yu; Kanoh, Soichiro; Shinoda, Masahiro; Kawano, Shuichi; Fujikura, Yuji; Kawana, Akihiko; Shinkai, Masaharu
• Is Part Of: Respiratory medicine case reports. Volume 19(2016)
• Page Start: 21
• Page End: 23
• Publication Date: 2016
• Subjects: Camostat mesilate -- Drug cessation -- Drug-induced lung injury -- Drug lymphocyte stimulation test -- Eosinophilic pneumonia; BALF bronchoalveolar lavage fluid -- DLST drug lymphocyte stimulation test -- GGO ground glass opacities -- HRCT High-resolution computed tomography; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2016.06.005
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Camostat mesilate is in widespread clinical use mainly to treat chronic pancreatitis, and drug-induced lung injury has not been previously reported. However, pulmonary infiltration with peripheral blood eosinophilia appeared after taking camostat mesilate for ten days. The histological findings showed eosinophilic infiltration into the alveolar space and interstitum, and drug lymphocyte stimulation test of peripheral blood was positive. Both peripheral blood eosinophilia and pulmonary involvements improved two weeks later with the cessation of this drug. To the best of our knowledge, this case is the first report of camostat mesilate-induced acute eosinophilic pneumonia.