Acidic Co‐Catalysts in Cationic Gold Catalysis. Issue 46 (10th October 2016)

• Record Type: Journal Article
• Authors: Barrio, Pablo; Kumar, Manish; Lu, Zhichao; Han, Junbin; Xu, Bo; Hammond, Gerald B.
• Is Part Of: Chemistry. Volume 22:Issue 46(2016)
• Page Start: 16410
• Page End: 16414
• Publication Date: 2016-10-10
• Subjects: catalyst decay -- co-catalyst -- gold catalysis -- Lewis acid -- transition metal; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201603478
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A systematic study on the effects of Lewis or Brønsted acid co‐catalysts in gold‐catalyzed reactions was undertaken using representative reactions (O‐, N‐, and C‐nucleophilic additions to alkynes). Through these reactions, it was demonstrated that an acidic co‐catalyst can increase the catalyst turnover significantly, enabling practical reaction rates at competitive catalyst loadings (<1 mol %). Further investigation is currently underway to improve the understanding of the subtle principles underlying these experimental observations. Abstract : A systematic study on the effects of Lewis or Brønsted acid co‐catalysts in gold‐catalyzed reactions was undertaken using representative reactions (O‐, N‐, and C‐nucleophilic additions to alkynes). Through these reactions, it was demonstrated that an acidic co‐catalyst can increase the catalyst turnover significantly, enabling practical reaction rates at competitive catalyst loadings.