Association of angiotensin-converting enzyme insertion/deletion polymorphism with type 1 diabetic nephropathy: a meta-analysis. (20th October 2016)

• Record Type: Journal Article
• Authors: Xu, Hai-Yan; Liu, Ming-Ming; Wang, Xu; He, Xue-Yuan
• Is Part Of: Renal failure. Volume 38:Number 9(2016)
• Page Start: 1320
• Page End: 1327
• Publication Date: 2016-10-20
• Subjects: Type 1 diabetic nephropathy -- type 1 diabetes mellitus -- angiotensin-converting enzyme -- gene polymorphism -- meta-analysis; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.1080/0886022X.2016.1216707
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Objective: This study aimed to systematically evaluate the effect of an angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism on type 1 diabetic nephropathy (DN). Methods: Cochrane Library, Embase, PubMed, Science Direct, Web of science, Wanfang data, VIP database, China Knowledge Resource Integrated Database, and SinoMed were searched. A total of 17 case–control studies analyzing ACE I/D polymorphism and type 1 DN risk were included in the present meta-analysis. Results: Overall, a significant increased risk was found in allele comparison (OR = 1.16, 95% CI = 1.05–1.28, p = 0.04), dominant comparison (OR = 1.56, 95% CI = 1.14–2.15, p = 0.006) and homozygote comparison (OR = 1.52, 95% CI = 1.06–2.19, p = 0.02). In subgroup analyses according to ethnicity, the risk of type 1 DN in Asian population was increased in allele comparison (OR = 1.98, 95% CI = 1.15–3.42, p = 0.01), recessive comparison (OR = 2.48, 95% CI = 1.51–4.10, p = 0.0004), dominant comparison (OR = 3.15, 95% CI = 1.90–5.23, p < 0.00001), and homozygote comparison (OR = 2.87, 95% CI = 1.02–8.06, p = 0.05). However, there was no association between the ACE I/D genetic variants and type 1 DN in Caucasian populations. Conclusions: Our meta-analysis results indicate that the ACE I/D polymorphism may contribute to type 1 DN development, especially in the Asian groups with type 1 diabetes. The current findings need to be confirmed by future well-designed and larger sample size primary studies in populations with different ethnicities.