Glucosylated pH-sensitive liposomes as potential drug delivery systems. (October 2016)

• Record Type: Journal Article
• Authors: Giansanti, Luisa; Mauceri, Alessandro; Galantini, Luciano; Altieri, Barbara; Piozzi, Antonella; Mancini, Giovanna
• Is Part Of: Chemistry and physics of lipids. Volume 200(2016)
• Page Start: 113
• Page End: 119
• Publication Date: 2016-10
• Subjects: Glucosylated amphiphile -- pH-sensitivity -- Liposomes -- Agglutination -- Concanavalin a -- Drug release; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipids; Periodicals; Electronic journals; 547.77
• DOI: 10.1016/j.chemphyslip.2016.08.004
• Languages: English
• ISSNs: 0009-3084

Abstract

Graphical abstract: Highlights: A new glucosylated pH-sensitive amphiphile was prepared and characterized. Glycosylated liposomes were investigated by DLS, DSC and fluorescence experiments. pH-sensitive liposomes show different properties than their cationic analogues. pH-sensitivity greatly influences lipid bilayer organization. The interaction of glycosylated pH-sensitive liposomes with Concanavalin A. Abstract: The inclusion of pH-sensitive components in liposome formulations can allow a more controlled and efficient release in response to low pH typical of some pathological tissues and/or subcellular compartments. On the other hand decorating the surface of liposomes with sugar moieties attributes to lipid vesicles specificity toward lectins, sugar-binding proteins overexpressed in many tumor tissues. A novel multifunctional pH-sensitive glucosylated amphiphile was synthesized and characterized as pure aggregate component and in mixtures with a natural phospholipid. The comparison of the properties of the new glucosylated amphiphile with respect to those of a previously described cationic structural analogue demonstrates that the pH-sensitivity can strongly affect drug release, lipid organization, as well as the exposure of the glucose residues on liposome surface and their ability to interact with Concanavalin A, a plant lectin used as model system.