Biodegradable Passion Fruit‐Like Nano‐Architectures as Carriers for Cisplatin Prodrug. (19th October 2016)

• Record Type: Journal Article
• Authors: Cassano, Domenico; Santi, Melissa; Cappello, Valentina; Luin, Stefano; Signore, Giovanni; Voliani, Valerio
• Is Part Of: Particle and particle systems characterization. Volume 33:Number 11(2016:Nov.)
• Page Start: 818
• Page End: 824
• Publication Date: 2016-10-19
• Subjects: biodegradation -- cisplatin -- gold nanoparticle -- hollow silica -- human pancreatic carcinoma; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201600175
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract : Accumulation of inorganic nanostructures in the excretory system organs increases their likelihood of toxicity and interference with common medical diagnoses. Thus, one of the major concerns regarding their clinical translation is related to their persistence in organisms. Here the authors demonstrate that nano‐architectures composed by hollow silica nanocapsules embedding arrays of ultrasmall gold nanoparticles undergo biodegradation in cellular environment affording small, potentially clearable building blocks. Furthermore, the authors present their exploitation in glutathione‐triggered release of covalently loaded cisplatin prodrug. This endogenously triggered release leads to high cytotoxicity to human pancreatic carcinoma cells, setting the way for promising applications to synergistic dual chemo/radio‐therapy and radio‐imaging. Abstract : Biodegradation in cellular environment of passion fruit‐like nano‐architectures is demonstrated together with their exploitation in glutathione‐triggered release of cisplatin toward human pancreatic carcinoma cells. Nanocapsules biodegrade to potentially kidney clearable building blocks, such as silicic acid, polymers, and ultrasmall gold nanoparticles. Such an approach is promising to engineer theranostics able to fill the gap between inorganic nanomaterials and oncology.