Is multivessel intervention in ST‐elevation myocardial infarction associated with early harm? Insights from observational data. Issue 5 (24th June 2016)

• Record Type: Journal Article
• Authors: Chatterjee, Saurav; Yeh, Robert W.; Sardar, Partha; Ul Hassan Virk, Hafeez; Mukherjee, Debabrata; Parikh, Sahil A.; Kumbhani, Dharam J.; Kirtane, Ajay; Bashir, Riyaz; Cohen, Howard; Kolansky, Daniel M.; Wilensky, Robert L.; Giri, Jay
• Is Part Of: Catheterization and cardiovascular interventions. Volume 88:Issue 5(2016)
• Page Start: 697
• Page End: 707
• Publication Date: 2016-06-24
• Subjects: acute myocardial infarction -- multi‐vessel disease -- percutaneous coronary intervention; Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.26643
• Languages: English
• ISSNs: 1522-1946

Abstract

Abstract : Objectives: Appraisal of evidence for recommendations for multivessel coronary intervention in ST‐elevation myocardial infarction (STEMI). Background: Multi‐vessel disease (MVD) is common in patients with ST‐segment elevation myocardial infarction (STEMI). Published observational data has suggested that multi‐vessel percutaneous coronary intervention (MVPCI) at the time of initial hospitalization for STEMI may be harmful in contrast to evidence from recent randomized trials. Methods: We queried the nationwide inpatient sample (NIS) to identify characteristics of hemodynamically stable STEMI patients undergoing MVPCI on index admission and subsequent mortality in raw and adjusted models. To compare our results with published observational data, we searched multiple databases from inception through July 15, 2015. Results: From 2009–2012, excluding cardiac arrest or cardiogenic shock, there were 11, 454 MVPCI and 157, 011 single‐vessel PCI (SVPCI) for STEMI patients in the NIS. Compared to SVPCI, MVPCI on index admission was not associated with higher in‐hospital mortality in unadjusted or propensity‐adjusted models (MVPCI 1.91% vs. SVPCI 5.32%, P < 0.001). Our analysis of index hospitalization MVPCI versus infarct‐related artery (IRA)—only PCI in the meta‐analysis of observational studies (19 studies, N = 76, 399) demonstrated no difference in in‐hospital mortality with MVPCI compared with IRA‐only PCI (OR 0.87, 95% CI 0.65–1.17; P = 0.37), with confirmation in study sequential analysis. Conclusions: MVPCI is uncommonly performed during index hospitalization in hemodynamically stable STEMI patients, likely reflecting widespread adherence to prior guidelines. Based on observational data, there does not appear to be early harm associated with MVPCI on the index admission in hemodynamically stable STEMI patients. © 2016 Wiley Periodicals, Inc.