A current snapshot of common genomic variants contribution in psychiatric disorders. Issue 8 (3rd August 2016)

• Record Type: Journal Article
• Authors: Santoro, Marcos L.; Moretti, Patricia N.; Pellegrino, Renata; Gadelha, Ary; Abílio, Vanessa C.; Hayashi, Mirian A.F.; Belangero, Sintia I.; Hakonarson, Hakon
• Is Part Of: American journal of medical genetics. Volume 171:Issue 8(2016)
• Page Start: 997
• Page End: 1005
• Publication Date: 2016-08-03
• Subjects: GWAS -- psychiatry -- polygenic risk score -- psychiatric disorder; Neuropsychiatry -- Periodicals; Medical genetics -- Periodicals; 616.8904205
• DOI: 10.1002/ajmg.b.32475
• Languages: English
• ISSNs: 1552-4841

Abstract

Abstract : In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. © 2016 Wiley Periodicals, Inc.