Efficient synthesis of D6‐clenproperol and D6‐cimaterol using deuterium isopropylamine as labelled precursor. (17th October 2016)

• Record Type: Journal Article
• Authors: Sun, Kai; Fang, Chao; Yang, Weicheng; Xu, Zhongjie; Wang, Haoran; Sun, Wen; Luo, Yong; Xu, Yi
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 59:Number 13(2016)
• Page Start: 552
• Page End: 556
• Publication Date: 2016-10-17
• Subjects: D6‐cimaterol -- D6‐clenproperol -- deuterium isopropylamine -- labelled internal standards -- synthesis; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3447
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : This report presents an efficient synthesis of D6 ‐clenproperol and D6 ‐cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor. Their structures and the isotope‐abundance were confirmed by proton nuclear magnetic resonance and liquid chromatography–mass spectrometry. Abstract : An efficient synthesis of D6 ‐clenproperol and D6 ‐cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor.