Synthesis of stable isotope labeled D9‐Mabuterol, D9‐Bambuterol, and D9‐Cimbuterol. (13th October 2016)

• Record Type: Journal Article
• Authors: Tu, Yahui; Zhong, Jiaqi; Wang, Haoran; Pan, Jie; Xu, Zhongjie; Yang, Weicheng; Luo, Yong
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 59:Number 13(2016)
• Page Start: 546
• Page End: 551
• Publication Date: 2016-10-13
• Subjects: β‐agonist -- internal standards -- isotope labeling -- synthesis; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3446
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : Three stable and simple synthetic routes of labeled D9 ‐Mabuterol, D9 ‐Bambuterol, and D9 ‐Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope‐abundance were confirmed according to 1 H NMR and liquid chromatography‐tandem mass spectrometry. Abstract : Three stable and simple synthetic routes of labeled D9 ‐Mabuterol, D9 ‐Bambuterol, and D9 ‐Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity.