Brain STAT5 signaling and behavioral control. (15th December 2016)

• Record Type: Journal Article
• Authors: Furigo, Isadora C.; Ramos-Lobo, Angela M.; Frazão, Renata; Donato, J.
• Is Part Of: Molecular and cellular endocrinology. Volume 438(2016)
• Page Start: 70
• Page End: 76
• Publication Date: 2016-12-15
• Subjects: Hypothalamus -- Maternal behavior -- Feeding -- Prolactin -- Leptin -- Growth hormone; AgRP agouti-related protein -- ARH arcuate nucleus of the hypothalamus -- CISH cytokine-inducible SH2-containing protein -- CREB cyclic AMP response element-binding protein -- ERK extracellular signal regulated kinase -- ERα estrogen receptor α -- GH growth hormone -- GM-CSF granulocyte macrophage colony-stimulating factor -- KO knockout -- LepR leptin receptor -- MPO medial preoptic area -- NPY neuropeptide Y -- PI3K phosphatidylinositol-4, 5-bisphosphate 3-kinase -- PrlR prolactin receptor -- SOCS3 suppressor of cytokine signaling 3 -- STAT5 Signal Transducer and Activator of Transcription 5; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2016.04.019
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway to control cell proliferation, differentiation and apoptosis. Nonetheless, the importance of this transcription factor for brain functions is still poorly understood. Because some STAT5-inducing hormones, such as prolactin and leptin, act in the brain to regulate the expression of motivated behaviors, this signaling pathway is likely involved in behavioral modulation. Therefore, the objective of the present review was to summarize and discuss the available data regarding the possible role of central STAT5 signaling in the regulation of brain functions, especially on behavioral control. We discussed studies that investigated the importance of STAT5 signaling in the regulation of maternal and feeding behaviors. Additionally, we highlighted other behaviors that could be potentially affected by STAT5 signaling. This knowledge may help to understand how motivated behaviors are regulated at the cellular level. Graphical abstract: Highlights: STAT5 is a key transcription factor recruited by many growth factors and cytokines. Brain STAT5 signaling is not required for maternal behavior expression in mice. STAT5 signaling regulates feeding behavior. Several other behaviors can be potentially affected by STAT5 signaling.