Perturbation of the molecular clockwork in the SCN of non-obese diabetic mice prior to diabetes onset. (25th November 2016)

• Record Type: Journal Article
• Authors: Ingenwerth, Marc; Reinbeck, Anna Lena; Stahr, Anna; Partke, Hans-Joachim; Roden, Michael; Burkart, Volker; von Gall, Charlotte
• Is Part Of: Chronobiology international. Volume 33:Number 10(2016)
• Page Start: 1369
• Page End: 1375
• Publication Date: 2016-11-25
• Subjects: Clock genes -- diabetes -- master clock molecular clockwork -- NOD -- photoentrainment; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.1080/07420528.2016.1218500
• Languages: English
• ISSNs: 0742-0528

Abstract

ABSTRACT: Circadian disruption is associated with the development of diabetes. Non-obese diabetic (NOD) mice show abnormal diurnal profiles in energy balance and locomotor activity suggesting circadian misalignment. Therefore, we analyzed cFos and mPER1 as markers for rhythmic neuronal activity within the suprachiasmatic nucleus (SCN) of wildtype (WT) and non-diabetic (nNOD) as well as acutely diabetic NOD (dNOD) mice. cFos levels show a day/night difference in both WT and nNOD but not in dNOD. mPER1 levels did not show a day/night difference in both nNOD and dNOD. This suggests that disruption of SCN rhythmicity in NOD mice precedes the actual onset of diabetes.