Mucus‐Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces. Issue 21 (26th September 2016)

• Record Type: Journal Article
• Authors: Yu, Tao; Chisholm, Jane; Choi, Woo Jin; Anonuevo, Abraham; Pulicare, Sarah; Zhong, Weixi; Chen, Minmin; Fridley, Colleen; Lai, Samuel K.; Ensign, Laura M.; Suk, Jung Soo; Hanes, Justin
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 21(2016)
• Page Start: 2745
• Page End: 2750
• Publication Date: 2016-09-26
• Subjects: curcumin -- drug delivery -- mucus penetrating particles -- nanocrystals -- nanotechnology; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201600599
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Mucus‐penetrating nanosuspensions, consisting of pure hydrophobic therapeutics with dense muco‐inert coatings that enable particles to effectively bypass the mucus barrier, demonstrate superior drug distribution and absorption at mucosal surfaces. With significantly increased drug load compared to polymeric systems and established clinical translation of nanosuspensions‐based products, mucus‐penetrating nanosuspensions are a promising vehicle for improving mucosal delivery of poorly soluble drugs.