A Highly Efficient Copper‐Mediated Radioiodination Approach Using Aryl Boronic Acids. Issue 47 (12th October 2016)

• Record Type: Journal Article
• Authors: Zhang, Pu; Zhuang, Rongqiang; Guo, Zhide; Su, Xinhui; Chen, Xiaoyuan; Zhang, Xianzhong
• Is Part Of: Chemistry. Volume 22:Issue 47(2016)
• Page Start: 16783
• Page End: 16786
• Publication Date: 2016-10-12
• Subjects: copper catalysts -- molecular imaging -- radiochemistry -- radioiodination -- radiopharmaceuticals; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201604105
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A convenient and quantitative radioiodination method by copper‐mediated cross‐coupling of aryl boronic acids was developed. The mild labeling conditions, ready availability of the boronic acid substrate, simple operation, broad functional group tolerance and excellent radiochemical yield (RCY) make this a practical strategy for radioiodine labeling without further purification. Abstract : A convenient and quantitative radioiodination method was developed by using a copper‐mediated cross‐coupling of aryl boronic acids with high radiochemical yields (RCY) under mild labeling conditions. The variety of precursors, simple operation, and broad functional‐group tolerance make it practical for radioiodine labeling without further purification.