Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion. Issue 21 (24th August 2016)

• Record Type: Journal Article
• Authors: Kohler, Sylvia; Voß, Franziska; Gómez Mejia, Alejandro; Brown, Jeremy S.; Hammerschmidt, Sven
• Is Part Of: FEBS letters. Volume 590:Issue 21(2016)
• Page Start: 3820
• Page End: 3839
• Publication Date: 2016-08-24
• Subjects: antibacterial therapy -- immune response -- lipoprotein -- Streptococcus pneumoniae -- virulence; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12352
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Streptococcus pneumoniae (pneumococcus) has evolved sophisticated strategies to survive in several niches within the human body either as a harmless commensal or as a serious pathogen causing a variety of diseases. The dynamic interaction between pneumococci and resident host cells during colonization of the upper respiratory tract and at the site of infection is critical for bacterial survival and the development of disease. Pneumococcal lipoproteins are peripherally anchored membrane proteins and have pivotal roles in bacterial fitness including envelope stability, cell division, nutrient acquisition, signal transduction, transport (as substrate‐binding proteins of ABC transporter systems), resistance to oxidative stress and antibiotics, and protein folding. In addition, lipoproteins are directly involved in virulence‐associated processes such as adhesion, colonization, and persistence through immune evasion. Conversely, lipoproteins are also targets for the host response both as ligands for toll‐like receptors and as targets for acquired antibodies. This review summarizes the multifaceted roles of selected pneumococcal lipoproteins and how this knowledge can be exploited to combat pneumococcal infections. Abstract :