Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits. (2nd October 2016)

• Record Type: Journal Article
• Authors: Wu, Xingxing; Chen, Yulin; Gui, Shuangying; Wu, Xiaoqing; Chen, Lei; Cao, Yingji; Yin, Dengke; Ma, Ping
• Is Part Of: Pharmaceutical development and technology. Volume 21:Number 7(2016)
• Page Start: 787
• Page End: 793
• Publication Date: 2016-10-02
• Subjects: Dissolving microneedle -- sinomenine hydrochloride -- transdermal drug delivery; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2015.1055766
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.